Uninstalling unwanted software sometimes is not possible outside Safe Mode.  There are times when removal of programs and drivers is necessary because they are preventing Windows from booting or may be infected with a virus or adware.
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Accessing Safe Mode in Windows 10 at boot time in an easy manner has been one of the most frustrating oversights by Microsoft. Since Windows 10, tapping on 'F8' to enter safe mode no longer works. 
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